Publications
Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ. Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell 173(3), 624-633.e8 (2018).
Bae J, Hideshima T, Zhang GL, Zhou J, Keskin DB, Munshi NC, Anderson KC. Identification and characterization of HLA-A24 specific XBP1, CD138 (Syndecan-1), and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma. Leukemia 32(3):752-764 (2018).
Yoshikawa A, Bi K, Keskin DB, Zhang G, Reinhold B, Reinherz EL. TCR-pMHC encounter differentially regulates transcriptomes of- tissue-resident CD8 T cells. Eur J Immunol 48(1):128-150 (2018).
Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature 547(7662), 217-221 (2017).
Abelin JG, Keskin DB, Sarkizova S, Hartigan CR, Zhang W, Sidney J, Stevens J, Lane W, Zhang GL, Eisenhaure TM, Clauser KR, Hacohen N, Rooney MS, Carr SA, Wu CJ. Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction. Immunity 46, 315–326 (2017).
Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P, Najjar S, Cao Y, Sands W, Keskin DB, Stern JN. Advancing drug delivery systems for the treatment of multiple sclerosis. Immunol Res 63(1-3):58-69 (2015).
Keskin DB, Reinhold B, Zhang GL, Ivanov A, Karger B, Reinherz EL. Reply to van de Sandt and Rimmelzwann: Matching epitope display with functional avidity. Proc Natl Acad Sci U S A 112(19): E2418 (2015).
Bae J, Keskin DB, Cowens K, Hwee LA, Dranoff G, Munshi NC, Anderson KC. Lenalidomide polarizes Th1-specific Anti-tumor immune response and expands XBP1 antigen specific central memory CD3+CD8+ T cells against various tumors. J Leuk 3: 178 (2015).
Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Jia-Huai W, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T cell receptor subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A 112(5):1517-22 (2015).
Recent meeting abstracts
Keskin DB, Sarkizova S, Klaeger S, Letitia L, Le PM, Keshishian H, Hartigan CR, Zhang GL, Clauser K, Carr SA, Hacohen N, Wu CJ. Systematic profiling of HLA-C epitopes [abstract].Immunology for American Association for Immunology Annual Meeting 2018.
Keskin DB, Tirosh I, Anandappa A, Sun J, Mathewson ND, Shukla SA, Gjini E, Li S, Li L, Giobbie-Hurder A, Le PM, Hu Z, Zhang W, Olive O, McCluskey C, Daley H, Wen PY, Chiocca AE, Harden M, Lennon N. Gabriel S, Getz G, Neuberg D, Ritz J, Lander ES, Regev A, Wucherpfennig K, Suva M, Fritsch EF, Scott R, Ligon KL, Livak KJ, Hacohen N, Ott PA, Wu CJ, Reardon DA. Personal neoantigen-targeting vaccination generates neoepitope-specific T cell responses in tumors of patients with glioblastoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5631.
Anandappa AJ, Keskin DB, Hu Z, Sun J, Tirosh I, Mathewson ND, Shukla SA, Li S, Olive O, Neuberg D, Fritsch EF, Livak KJ, Hacohen N, Ott PA, Reardon DA, Wu CJ. Detecting neoepitope-specific intra-tumoral T cell responses in a glioblastoma patient treated with personal neoantigen vaccine [abstract]. In: Journal of Immunology for American Association for Immunology Annual Meeting 2018. J Immunol May 1, 2018, 200 (1 Supplement) 181.11